Synthesis and pharmacological characterization of 5-(2-dodecylphenyl)-4,6-dithianonanedioic acid and 5-[2-(8-phenyloctyl)phenyl]-4,6-dithianonanedioic acid: prototypes of a novel class of leukotriene antagonists

J Med Chem. 1985 Sep;28(9):1145-7. doi: 10.1021/jm00147a004.
No abstract available

Publication types

  • Comparative Study

MeSH terms

  • Airway Resistance / drug effects
  • Animals
  • Chemical Phenomena
  • Chemistry
  • Chromones / pharmacology
  • Dicarboxylic Acids / chemical synthesis
  • Dicarboxylic Acids / pharmacology*
  • Dose-Response Relationship, Drug
  • Guinea Pigs
  • Lung Compliance / drug effects
  • Muscle Contraction / drug effects
  • Receptors, Leukotriene
  • Receptors, Prostaglandin / drug effects
  • SRS-A / antagonists & inhibitors*
  • Trachea / physiology

Substances

  • Chromones
  • Dicarboxylic Acids
  • Receptors, Leukotriene
  • Receptors, Prostaglandin
  • SRS-A
  • FPL 55712
  • 5-(2-dodecylphenyl)-4,6-dithianonanedioic acid
  • 5-(2-(8-phenyloctyl)phenyl)-4,6-dithianonanedioic acid